Prevalence of osteoporosis in patients with nephrolithiasis and vice versa: a cumulative analysis
Prevalence of osteoporosis in patients with nephrolithiasis and vice versa: a cumulative analysis
Blog Article
PurposeNephrolithiasis is thought to be a risk factor for osteoporosis, but data assessing if osteoporosis predisposes to the risk of nephrolithiasis are lacking.The present study aims to investigate whether patients with nephrolithiasis have a prominently higher prevalence of osteoporosis than the controls and vice versa via a cumulative analysis.MethodsFour databases were used to detect the eligible studies.
We calculated the relative risk (RR) with a 95% confidence interval (CI) to assess the combined effect.The methodologies for conducting this study followed the PRISMA guidelines and were registered in the Latest Product Releases & Innovations – Stay Updated! PROSPERO (ID: CRD42023395875),ResultsNine case-control or cohort studies with a total of 454,464 participants were finally included.Combined results indicated that there was a significantly higher prevalence of osteoporosis in patients with nephrolithiasis as compared to the general population without nephrolithiasis (overall RR from six studies= 1.
204, 95%CI: 1.133 to 1.28, P< 0.
001; heterogeneity: I2 = 34.8%, P= 0.162).
Conversely, osteoporosis was significantly correlated to an increased risk of nephrolithiasis as compared to the controls without osteoporosis (overall RR from four studies= 1.505, 95%CI: 1.309 to 1.
731, P< 0.001; I2 = 89.8%, P< 0.
001).Sensitivity analysis on the two categories validated the above findings.No significant publication bias was identified in this study.
ConclusionsThe present study highlighted a significantly high prevalence of osteoporosis in patients with nephrolithiasis and vice versa.This reciprocal association reminded the clinicians to conduct a regular nacrack.com follow-up assessment when managing patients with nephrolithiasis or osteoporosis, especially for the elderly.Systematic review registrationhttps://www.
crd.york.ac.
uk/PROSPERO/#searchadvanced, identifier CRD42023395875.